Health and Lifestyle for the over 50s

The Gene That Could Suppress Cancer

Posted by The Best of Health
Categories: Health and Wellbeing /

cancer-135110135

Scientists have discovered that a particular gene may be able to play a role in suppressing cancer. The gene, called the glucocorticoid receptor (GR), can be found in almost every cell in the body, and has previously been linked to cell development, immune response and metabolism.

Researchers at the University of Manchester found that in cells lacking GR, cell division was disrupted and errors in chromosomes appeared – occurrences which can contribute to the development of cancer. To further investigate the effects of a lack of GR, they reduced GR expression in mice, and observed an increase in tumours as they aged. The tumours were found to have even less GR than the surrounding normal tissue.

“Cancer is caused by cell division going wrong, but no one has previously looked at the role GR has to play in this process,” says research leader Professor David Ray, from the University’s Institute of Human Development. “It’s now clear that it is vital.”

Analysis of several common human cancers revealed that reduced GR expression is a common feature in certain cancer cell types. The findings imply that GR could possibly act as a tumour suppressor, and the research team hope that the discovery of the relationship between GR and cancer progression will be a step towards more effective treatments for the disease.

Lead author Laura Matthews concludes: “We do need to add more research to these findings, but this new mechanism adds a lot more to our knowledge of how cancers form, and with that knowledge we’re much better equipped to develop new treatments which could eventually be used in humans.”

Related Posts

Posted by The Best of Health

We use cookies to give you the best online experience. By agreeing you accept the use of cookies in accordance with our cookie policy.

Privacy Settings saved!
Privacy Settings

When you visit any web site, it may store or retrieve information on your browser, mostly in the form of cookies. Control your personal Cookie Services here.

These cookies allow us to count visits and traffic sources, so we can measure and improve the performance of our site.

In order to use this website we use the following technically required cookies
  • wordpress_test_cookie

We use Google Tag Manager to monitor our traffic and to help us AB test new features.

Decline all Services
Accept all Services
X